Anti-cancer effect of engineered recombinant interleukin 18
نویسندگان
چکیده
منابع مشابه
Immunologic Function and Molecular Insight of Recombinant Interleukin-18
In recent years, cytokine-mediated therapy has emerged as further advance alternative in cancer therapy. Interleukin-18 (IL-18) has exhibited interesting anti-cancer properties especially when combined with IL-12. We engineered IL-18 in order to improve its activity using single point mutagenesis. IL-18 mutants were constructed according to binding residues and polarity which we tried to increa...
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In order to increase the productivity of human interleukin-2 (IL-2) as a model protein in the recombinant E.coliBL21 (DE3), the effect of magnesium acetate and manganese acetate was studied based on full factorial design experiments magnesium acetate and manganese acetate and their interaction exhibited an increasing effect on IL-2 expression level upto 25.24%, 16.80% and 23.30%, respective...
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ژورنال
عنوان ژورنال: Advances in Clinical and Experimental Medicine
سال: 2020
ISSN: 1899-5276
DOI: 10.17219/acem/126298